000			04447cam a2200529 i 4500
999			_c10801 _d10801
001			19042201
003			GZU
005			20221018142748.0
008			160404t20172017ne ac b 001 0 eng c
010			_a 2016937836
016	7		_a101717203 _2DNLM
020			_a9780128036204 (hbk.)
020			_a0128036206 (hbk.)
022			_a9780128036204
035			_a(OCoLC)ocn972508192
040			_aNLM _beng _cNLM _erda _dOCLCF _dLIP _dAU@ _dOCLCO _dDLC
042			_apcc
050	0	0	_aRA1238 _b.COM 2017
130	0		_aComprehensive guide to toxicology in preclinical drug development.
245	1	2	_aA comprehensive guide to toxicology in nonclinical drug development / _cedited by Ali Said Faqi,
250			_aSecond edition.
264		1	_aAmsterdam : _bAcademic Press is an imprint of Elsevier, _c[2017]
264		4	_c©2017
300			_axiii, 971 pages : _billustrations (some color), portraits ; _c29 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
500			_aPreceded by Comprehensive guide to toxicology in preclinical drug development / edited by Ali S. Faqi. 1st ed. 2013.
504			_aIncludes bibliographical references and index.
505			_a1. Introduction; 2. ADME in Drug Discovery; 3. Pharmacokinetics and Toxicokinetics; 4. Acute, Sub-Acute, Sub-Chronic and Chronic, Dermal and Inhalation Toxicology; 5. Contemporary Practices in Core Safety Pharmacology Assessments; 6. Genetic Toxicology Testing; 7. Clinical Pathology; 8. Best Practice in Toxicologic Pathology; 9. Molecular Pathology: Applications in Nonclinical Drug Development; 10. Infusion Toxicology and Techniques; 11. The Preparation of a Nonclinical Dossier to Support an Investigational New Drug (IND) Application and First-in-Human Clinical Trials; 12. Developmental and Reproductive Toxicology; 13. Immunotoxicology Assessment in Drug Development; 14. Juvenile Toxicity Testing to Support Clinical Trials in the Pediatric Population; 15. Photosafety: Current Methods and Future Direction; 16. Dermal Toxicology; 17. Inhalation Toxicology; 18. Nonclinical Evaluation of Carcinogenicity using the Rodent Two-Year Bioassay and Carcinogenicity Evaluations using Genetically Engineered Animals; 19 Current Strategies for Abuse Liability Assessment of New Chemical Entities; 20. Nonclinical Development of Monoclonal Antibodies; 21. Nonclinical Development of Non-Oncogenic Drugs (Small and Large Molecules); 22. Nonclinical Development of Oncology Drugs; 23. Safety Evaluation of Ocular Drugs; 24. Nonclinical toxicology of Vaccines; 25. Stem Cells In Nonclinical Toxicology; 26. Overview of the Nonclinical Development Strategies and Class-Effects of Oligonucleotide-Based Therapeutics; 27. Nonclinical Safety Assessment of Botanical Drugs; 28. Regulatory Toxicology; 29. Biostatistics for Toxicologists; 30. Role of Study Director and Study Monitor in Drug Development; 31. Use of Imaging for Nonclinical Evaluation; 32. Biomarkers in Toxicology; 33. Predictive Toxicology: Biological Assay Platforms; 34. Toxicometabolomics: Technology and Applications; 35. Toxicogenomics in Nonclinical Development; 36. Nonclinical Testing of Medical Devices; 37. The Pitfalls of Drug Development
520			_aThis book is designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more
650		0	_aDrugs _xToxicology.
650		0	_aDrug development.
650		0	_aClinical toxicology.
650	1	2	_aDrug Evaluation _xmethods.
650	2	2	_aDrug Discovery.
650	2	2	_aDrug-Related Side Effects and Adverse Reactions _xprevention & control.
650	2	2	_aToxicity Tests _xmethods.
650		7	_aClinical toxicology. _2fast _0(OCoLC)fst00864428
650		7	_aDrug development. _2fast _0(OCoLC)fst00898670
650		7	_aDrugs _xToxicology. _2fast _0(OCoLC)fst00898958
700	1		_aFaqi, Ali S., _eeditor.
906			_a7 _bcbc _cpccadap _d2 _encip _f20 _gy-gencatlg
942			_2lcc _cBK _eSecond edition _h1238 _iCOM _kRA