000			03625 a2200313 4500
999			_c10785 _d10785
020			_a9780128029381
050			_aQP552 _bFIS 2015
100			_aFisher, Rory A. _eeditor
245			_a RGS Protein Physiology and Pathophysiology / _cRory A. Fisher
264			_aAmsterdam : _bElsevier/Academic Press, _c2015
300			_axii, 213 pages : _billustrations
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
440			_aProgress in molecular biology and translational science
500			_an/a
504			_aIncludes bibliographical references and index
505			_aRGS Protein Regulation of Phototransduction1. Introduction; 2. From Photon to a Neural Signal: The Wonder of Phototransduction; 3. The Need for Speed: Discrepancy on G-Protein Shutoff During Phototransduction Recovery; 4. Cannot Do It Alone: The Transducin GAP Is a Protein Complex; 5. Translocation and Regulation of RGS9-1; 6. Conclusions: Emerging Functions of RGS Proteins in the Visual System; References; Chapter Four: Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology; 1. Introduction to Bone; 2. The GPCR-G Protein-RGS Signaling Pathway. 2.1. The G Protein Complex2.2. Introduction to RGS Proteins; 3. RGS Proteins in Osteoblasts; 3.1. RGS2 in Osteoblasts; 3.2. RGS5 in Osteoblasts; 3.3. Axin in Osteoblasts; 4. RGS Proteins in Osteoclasts; 4.1. RGS10 in Osteoclasts; 4.2. RGS12 in Osteoclasts; 4.3. RGS18 in Osteoclasts; 5. GPCR-RGS Proteins Signaling in Skeletal Physiology; 5.1. RGS Proteins and PTH/PTHrP Signaling in Bone; 5.2. RGS Proteins and Wnt Signaling in Bone; 5.3. RGS Proteins and Ca2+ Oscillations; 6. GPCR/RGS Signaling in Skeletal Disorders; 6.1. PTH1R and GPCR 48 in Skeletal Development and Diseases. 6.2. CaSR in Skeletal Development and Disease6.3. The Canonical Wnt Signaling Pathway in Bone Disease; 6.3.1. Axin in Bone Development and Bone Disease; 6.3.2. Mouse Models of Wnt Signaling in Skeletal Homeostasis; 6.3.3. Bone Diseases of Defective Wnt Signaling; 6.4. RGS Proteins in Inflammatory Bone Disease; 7. Conclusion and Perspectives; Acknowledgments; References; Chapter Five: Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function; 1. Introduction; 2. Structure and Biochemical Functions of RGS2; 3. Regulation of RGS2 Expression
520			_aRGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery
650			_aBiochemistry
650			_aG proteins Physiological effect
650			_aG proteins Receptors
650			_aMolecular Biology
650			_aMolecular biology
650			_aProteins Physiological transport
650			_amolecular biology
700			_aFisher, Rory A. _eauthor
942			_2lcc _cBK _h552 _iFIS _kQP