000			04504 a2200241 4500
999			_c10747 _d10747
020			_a9780128013823 (hbk)
050			_aQL955 _b. CUR 2007
100			_aSchatten, Gerald _eeditor
245	0	0	_aCurrent topics in developmental biology : _bessays on developmental biology, part B / _cedited by Paul M. Wassarman, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
250			_aFirst edition.
264		1	_aAmsterdam : _aBoston : _bElsevier/AP, _c2016.
300			_axxiv, 710 pages : _billustrations (some color) ;
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
440			_aCurrent topics in developmental biology
504			_aIncludes index
505			_aFront Cover; Current Topics in Developmental Biology; Copyright Page; Contents; Contributors; I. Introduction; A. Joint Morphogenesis: Overview; II. Specification and Patterning of the Joint; A. The Limb Field and Joints; B. Formation of the Joint Interzone; III. Joint Cavitation and the Role of Mechanical Stimuli; IV. Cell-Matrix Interactions During Joint Formation; V. The Development of Articular Cartilage: Overview; VI. Aspects of Postnatal Joint Biology; References; Chapter 2: Development of a Sexually Differentiated Behavior and Its Underlying CNS Arousal Functions; I. Introduction II. Sexual Differentiation of Brain Mechanisms Producing Lordosis BehaviorA. Mechanisms; III. Development of Brain Mechanisms Underlying Arousal; IV. Outlook for New Work on Sexually Differentiated Behaviors; References; Chapter 3: Phosphodiesterases Regulate Airway Smooth Muscle Function in Health and Disease; I. Introduction; II. Developmental and Physiological Responses Regulated by PDEs; III. PDEs and Airway Smooth Muscle Function; A. PDE and ASM Tone and Contractility; B. PDE and ASM Growth and Migration; IV. Cytokine and Chemokine Secretion by ASM: A Role for PDEs; V. Conclusions AcknowledgmentsReferences; Chapter 4: Role of Astrocytes in Matching Blood Flow to Neuronal Activity; I. Introduction; II. Neurovascular Unit; III. Neuron-Astrocyte Interactions and Regulation of Synaptic Transmission in the Brain; A. Ca2+ Signaling in Astrocytes; B. Astrocyte Release of Glutamate and Modulation of Synaptic Transmission; C. Neurometabolic Coupling; IV. Neurovascular Coupling: Role of Astrocytes; A. Role of Astrocytic Ca2+ Elevations in Coupling Neuronal Activity to the Vasculature; B. Vasoactive Mediators of Neurovascular Coupling; V. Summary; References Chapter 5: Elastin-Elastases and Inflamm-AgingI. Introduction; A. The MMPs: Cytokines Interplay in Inflammation; B. MMPs as Matrix ""Decryptases""; C. Elastic Fibers Fragmentation and Aging; II. Elastic Fibers: Formation and Degradation; A. Synthesis and Association (Coacervation) of Tropoelastin Molecules; B. Development of Elastic Fibers; C. Elastases in Human; D. Mechanism of Elastin Degradation by Elastases; III. Biological Activities of Elastin Peptides (EPs): The ""Elastin Receptor System""; A. EPs as Modifiers of Cell Behavior; B. The S-Gal Complex C. Cell Signaling Pathways Mediated by S-Gal OccupancyIV. Elastolysis, Aging, and AAAs; A. Elastase(s)-Driven Elastin Fragmentation in Arterial Diseases: General Considerations; B. Proangiogenic Effect of EPs; C. Influence of EPs on T-Lymphocytes Polarization; V. The Elastin Connection in Melanoma; A. Aging, Fibroblasts Senescence, and Cancer Progression; B. EPs as Modifiers of the Dermal Stroma; C. EPs and Melanoma Progression; D. EPs-Mediated Angiogenic Phenotype; E. EPs and Inflamm-Aging in Melanoma; VI. Concluding Remarks; References.
520			_aThis serial provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. * Includes many descriptive figures * Topics covered include the the development of synovial joints, sexually differentiated behavior, mapping cell fate, and more * Latest volume in the series that covers six reviews in more than 220 pages.
650			_aBiology
942			_2lcc _cBK _h955 _iCUR _kQL