Supplementary material available via the World Wide Web.

Includes bibliographical references and index.

The Foundations of Biochemistry -- I. STRUCTURE AND CATALYSIS. Water -- Amino Acids, Peptides, and Proteins -- The Three-Dimensional Structure of Proteins -- Protein Function -- Enzymes -- Carbohydrates and Glycobiology -- Nucleotides and Nucleic Acids -- DNA-Based Information Technologies -- Lipids -- Biological Membranes and Transport -- Biosignaling -- II. BIOENERGETICS AND METABOLISM. Bioenergetics and Biochemical Reaction Types -- Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway -- Principles of Metabolic Regulation -- The Citric Acid Cycle-- Fatty Acid Catabolism -- Amino Acid Oxidation and the Production of Urea -- Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation -- Carbohydrate Biosynthesis in Plants and Bacteria -- Lipid biosynthesis -- Biosynthesis of Amino Acids, Nucleotides, and Related Molecules -- Hormonal Regulation and Integration of Mammalian Metabolism -- III. INFORMATION PATHWAYS. Genes and Chromosomes -- DNA Metabolism -- RNA Metabolism -- Protein Metabolism -- Regulation of Gene Expression.

"Clear writing and illustrations ... Clear explanations of difficult concepts ... Clear communication of the ways in biochemistry is currently understood and practiced. For over 35 years, in edition after bestselling edition, Principles of Biochemistry has put those defining principles into practice, guiding students through a coherent introduction to the essentials of biochemistry without overwhelming them. The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistry's foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research. These extensive content changes, as well as new art and powerful new learning technologies make this edition of Lehninger Principles of Biochemistry the most impressive yet." --Publisher description