Volume 6 1999
English

Includes bibliographical references and index

Cover; CONTENTS; LIST OF CONTRIBUTORS; INTRODUCTION TO THE SERIES; PREFACE; CHAPTER 1. PATHOGEN STRATEGIES: A HITCHIKER'S GUIDE TO THE MACROPHAGE; CHAPTER 2. ANTIPHAGOCYTOSIS BY YERSINIA: A MECHANISM INVOLVING PTPAsE-MEDIATED DISRUPTION OF HOST-CELL FOCAL COMPLEXES; CHAPTER 3. INVASION OF MAMMALIAN CELLS BY LISTERIA MONOCYTOGENES; CHAPTER 4. THE ROLE OF COMPLEMENT RECEPTOR TYPE 3 IN THE INVASION STRATEGIES OF MYCOBACTERIUM TUBERCULOSIS; CHAPTER 5. MYCOBACTERIA AND THE ENDOCYTIC PATHWAY CHAPTER 6. LEGIONELLA PNEUMOPHILA AND MYCOBACTERIUM TUBERCULOSIS: TWO PATHWAYS THROUGH THE MONONUCLEAR PHAGOCYTECHAPTER 7. PHAGOCYTOSIS OF PSEUDOMONAS AERUGINOSA; CHAPTER 8. INTERACTION OF SALMONELLA SPP WITH HOST CELLS; CHAPTER 9. SHIGELIA HOST CELL INVASION: SIGNIFICANCE IN PATHOGENESIS; CHAPTER 10. BRUCELLA ABORTUS INVASION AND SURVIVAL WITHIN PROFESSIONAL AND NONPROFESSIONAL PHAGOCYTES; CHAPTER 11. EN ROUTE TO THE VACUOLE: TRACING THE SECRETORY PATHWAY OF TOXOPLASMA GONDII; CHAPTER 12. ACTIVE CELL INVASION BY TOXOPLASMA GONDll LEADS TO AVOIDANCE OF PHAGOCYTIC PROCESSING CHAPTER 13. REGULATED EXOCYTOSIS OF LYSOSOMES: A NOVEL PATHWAY REVEALED BY THE INTERACTION OF TRYPANOSOMA CRUZI WITH HOST CELLSCHAPTER 14. PHAGOCYTOSIS OF LEISHMANIA: INTERACTION WITH THE HOST AND INTRACELLULAR TRAFFICKING; CHAPTER 15. CELLULAR MECHANISMS OF PHAGOCYTOSIS OF CANDIDA BY MURINE MACROPHAGES; CHAPTER 16. NONOPSONIC FIMH-MEDIATED PHAGOCYTOSIS OF E. COLI AND ITS POSSIBLE CONTRIBUTION TO RECURRENT URINARY TRACT INFECTIONS; CHAPTER 17. CELL CO-INFECTIONS WITH NONVIRAL PATHOGENS AND THE CONSTRUCTION OF DOUBLY INFECTED PHAGOSOMES; INDEX

The present volume focuses on microbial invasion strategies of pathogen uptake. An accompanying volume (Vol. 5) in the series presents the phagocytic process from the viewpiont of the host cell. This field of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research and brings together cell biologists, microbiologists, and immunologists wiht disthemes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular parasitism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pahtogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is becoming increasingly clear that large viruses (e.g. Vaccinia) and Listeria monocytogenes, share common strategies in invasion and intercellular spread