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Marks' basic medical biochemistry : a clinical approach / Michael Lieberman , Alisa Peet

By: Contributor(s): Philadelphia: Wolters Kluwer, 2018Edition: Fifth editionDescription: xii, 1051 pages : color illustrations ; 28 cmContent type:
  • rdacontent
Media type:
  • rdamedia
Carrier type:
  • rdacarrier
ISBN:
  • 9781496387721
Subject(s): LOC classification:
  • QP514.2 MAR 2018
Contents:
I: Fuel metabolism Metabolic fuels and dietary components The fed or absorptive state Fasting II: Chemical and biologic foundations of biochemistry Water, acids, bases, and buffers Structures of the major compounds of the body Amino acids in proteins Structure-function relationships in proteins Enzymes as catalysts Regulation of enzymes Relationship between cell biology and biochemistry Cell signaling by chemical messengers III: Gene expression and the synthesis of proteins Structure of the nucleic acids Synthesis of DNA Transcription: synthesis of RNA Translation: synthesis of proteins Regulation of gene expression Use of recombinant DNA techniques in medicine The molecular biology of cancer IV: Carbohydrate metabolism, fuel oxidation, and the generation of adenosine triphosphate Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones Cellular bioenergetics: adenosine triphosphate and O2 Digestion, absorption, and transport of carbohydrates Generation of adenosine triphosphate from glucose, fructose, and galactose: glycolysis Tricarboxylic acid cycle Oxidative phosphorylation and mitochondrial function Oxygen toxicity and free-radical injury Formation and degradation of glycogen Pentose phosphate pathway and the synthesis of glycosides, lactose, glycoproteins, and glycolipids Gluconeogenesis and maintenance of blood glucose levels V: Lipid metabolism Digestion and transport of dietary lipids Oxidation of fatty acids and ketone bodies Synthesis of fatty acids, triacylglycerols, and the major membrane lipids Cholesterol absorption, synthesis, metabolism, and fate Metabolism of ethanol Integration of carbohydrate and lipid metabolism VI: Nitrogen metabolism Protein digestion and amino acid absorption Fate of amino acid nitrogen: urea cycle Synthesis and degradation of amino acids Tetrahydrofolate, vitamin B12, and S-adenosylmethionine Purine and pyrimidine metabolism Intertissue relationships in the metabolism of amino acids VII: tissue metabolism Actions of hormones that regulate fuel metabolism The biochemistry of erythrocytes and other blood cells Blood plasma proteins, coagulation, and fibrinolysis Liver metabolism Metabolism of muscle at rest and during exercise Metabolism of the nervous system The extracellular matrix and connective tissue
Summary: Connect biochemistry to clinical practice! Marks' Basic Medical Biochemistry links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine - from diagnosing patients to recommending effective treatments. Intuitively organized chapters center on hypothetical patient vignettes, highlighting the material's clinical applications; helpful icons allow for smooth navigation, making complex concepts easier to grasp. Full-color illustrations make chemical structures and biochemical pathways easy to visualize. Patient vignettes connect biochemistry to human health and disease. Clinical Notes explain patient signs or symptoms, and Method Notes relate biochemistry to the laboratory tests ordered during diagnosis. Clinical Comments link biochemical dynamics to treatment options and patient outcomes. Biochemical Comments explore directions for new research. Key Concepts and Summary Disease tables highlight the take-home messages in each chapter. Questions and answers at the end of each chapter - 470 total inside the book, with 560 more online - probe students' mastery of key concepts
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Holdings
Item type Current library Home library Collection Call number Copy number Status Date due Barcode Item holds
Books Books Medical Library General Stacks Medical Library Non-fiction QP514.2 MAR 2018 (Browse shelf(Opens below)) C.1 Available 032819
Total holds: 0

Includes index

I: Fuel metabolism
Metabolic fuels and dietary components
The fed or absorptive state
Fasting
II: Chemical and biologic foundations of biochemistry
Water, acids, bases, and buffers
Structures of the major compounds of the body
Amino acids in proteins
Structure-function relationships in proteins
Enzymes as catalysts
Regulation of enzymes
Relationship between cell biology and biochemistry
Cell signaling by chemical messengers
III: Gene expression and the synthesis of proteins
Structure of the nucleic acids
Synthesis of DNA
Transcription: synthesis of RNA
Translation: synthesis of proteins
Regulation of gene expression
Use of recombinant DNA techniques in medicine
The molecular biology of cancer
IV: Carbohydrate metabolism, fuel oxidation, and the generation of adenosine triphosphate
Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones
Cellular bioenergetics: adenosine triphosphate and O2
Digestion, absorption, and transport of carbohydrates
Generation of adenosine triphosphate from glucose, fructose, and galactose: glycolysis
Tricarboxylic acid cycle
Oxidative phosphorylation and mitochondrial function
Oxygen toxicity and free-radical injury
Formation and degradation of glycogen
Pentose phosphate pathway and the synthesis of glycosides, lactose, glycoproteins, and glycolipids
Gluconeogenesis and maintenance of blood glucose levels
V: Lipid metabolism
Digestion and transport of dietary lipids
Oxidation of fatty acids and ketone bodies
Synthesis of fatty acids, triacylglycerols, and the major membrane lipids
Cholesterol absorption, synthesis, metabolism, and fate
Metabolism of ethanol
Integration of carbohydrate and lipid metabolism
VI: Nitrogen metabolism
Protein digestion and amino acid absorption
Fate of amino acid nitrogen: urea cycle
Synthesis and degradation of amino acids
Tetrahydrofolate, vitamin B12, and S-adenosylmethionine
Purine and pyrimidine metabolism
Intertissue relationships in the metabolism of amino acids VII: tissue metabolism
Actions of hormones that regulate fuel metabolism
The biochemistry of erythrocytes and other blood cells
Blood plasma proteins, coagulation, and fibrinolysis
Liver metabolism
Metabolism of muscle at rest and during exercise
Metabolism of the nervous system
The extracellular matrix and connective tissue

Connect biochemistry to clinical practice! Marks' Basic Medical Biochemistry links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine - from diagnosing patients to recommending effective treatments. Intuitively organized chapters center on hypothetical patient vignettes, highlighting the material's clinical applications; helpful icons allow for smooth navigation, making complex concepts easier to grasp. Full-color illustrations make chemical structures and biochemical pathways easy to visualize. Patient vignettes connect biochemistry to human health and disease. Clinical Notes explain patient signs or symptoms, and Method Notes relate biochemistry to the laboratory tests ordered during diagnosis. Clinical Comments link biochemical dynamics to treatment options and patient outcomes. Biochemical Comments explore directions for new research. Key Concepts and Summary Disease tables highlight the take-home messages in each chapter. Questions and answers at the end of each chapter - 470 total inside the book, with 560 more online - probe students' mastery of key concepts

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