MARC details
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9780128029381 |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QP552 |
| Item number |
FIS 2015 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fisher, Rory A. |
| Relator term |
editor |
| 245 ## - TITLE STATEMENT |
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| Title |
RGS Protein Physiology and Pathophysiology / |
| Statement of responsibility, etc. |
Rory A. Fisher |
| 264 ## - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
Amsterdam : |
| Name of producer, publisher, distributor, manufacturer |
Elsevier/Academic Press, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2015 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xii, 213 pages : |
| Other physical details |
illustrations |
| 336 ## - CONTENT TYPE |
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| Source |
rdacontent |
| Content type term |
text |
| Content type code |
txt |
| 337 ## - MEDIA TYPE |
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| Source |
rdamedia |
| Media type term |
unmediated |
| Media type code |
n |
| 338 ## - CARRIER TYPE |
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| Source |
rdacarrier |
| Carrier type term |
volume |
| Carrier type code |
nc |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE |
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| Title |
Progress in molecular biology and translational science |
| 500 ## - GENERAL NOTE |
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| General note |
n/a |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Includes bibliographical references and index |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
RGS Protein Regulation of Phototransduction1. Introduction; 2. From Photon to a Neural Signal: The Wonder of Phototransduction; 3. The Need for Speed: Discrepancy on G-Protein Shutoff During Phototransduction Recovery; 4. Cannot Do It Alone: The Transducin GAP Is a Protein Complex; 5. Translocation and Regulation of RGS9-1; 6. Conclusions: Emerging Functions of RGS Proteins in the Visual System; References; Chapter Four: Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology; 1. Introduction to Bone; 2. The GPCR-G Protein-RGS Signaling Pathway. 2.1. The G Protein Complex2.2. Introduction to RGS Proteins; 3. RGS Proteins in Osteoblasts; 3.1. RGS2 in Osteoblasts; 3.2. RGS5 in Osteoblasts; 3.3. Axin in Osteoblasts; 4. RGS Proteins in Osteoclasts; 4.1. RGS10 in Osteoclasts; 4.2. RGS12 in Osteoclasts; 4.3. RGS18 in Osteoclasts; 5. GPCR-RGS Proteins Signaling in Skeletal Physiology; 5.1. RGS Proteins and PTH/PTHrP Signaling in Bone; 5.2. RGS Proteins and Wnt Signaling in Bone; 5.3. RGS Proteins and Ca2+ Oscillations; 6. GPCR/RGS Signaling in Skeletal Disorders; 6.1. PTH1R and GPCR 48 in Skeletal Development and Diseases. 6.2. CaSR in Skeletal Development and Disease6.3. The Canonical Wnt Signaling Pathway in Bone Disease; 6.3.1. Axin in Bone Development and Bone Disease; 6.3.2. Mouse Models of Wnt Signaling in Skeletal Homeostasis; 6.3.3. Bone Diseases of Defective Wnt Signaling; 6.4. RGS Proteins in Inflammatory Bone Disease; 7. Conclusion and Perspectives; Acknowledgments; References; Chapter Five: Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function; 1. Introduction; 2. Structure and Biochemical Functions of RGS2; 3. Regulation of RGS2 Expression |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biochemistry |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
G proteins Physiological effect |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
G proteins Receptors |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Molecular Biology |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Molecular biology |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Proteins Physiological transport |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
molecular biology |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fisher, Rory A. |
| Relator term |
author |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Books |
| Classification part |
552 |
| Item part |
FIS |
| Call number prefix |
QP |
